Humanized anti-CD19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease

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United States of America Patent

PATENT NO 9896505
SERIAL NO

14509457

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Abstract

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The present invention provides chimeric and humanized versions of anti-CD19 mouse monoclonal antibodies. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human CD19 antigen and that may mediate ADCC, CDC, and/or apoptosis for the treatment of B cell diseases and disorders, such as, but not limited to, B cell malignancies, for the treatment and prevention of autoimmune disease, and for the treatment and prevention of graft-versus-host disease (GVHD), humoral rejection, and post-transplantation lymphoproliferative disorder in human transplant recipients.

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Patent Owner(s)

Patent OwnerAddress
VIELA BIO INC1 HORIZON WAY DEERFIELD IL 60015

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Coyle, Anthony Boston, US 42 360
Dall'Acqua, William Gaithersburg, US 47 1370
Damschroder, Melissa Gaithersburg, US 44 763
Herbst, Ronald Gaithersburg, US 30 89
Kiener, Peter Potomac, US 50 634
Wu, Herren Gaithersburg, US 110 2333

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