Mutated immunoglobulin-binding polypeptides

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United States of America Patent

PATENT NO 9896486
SERIAL NO

14903837

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Abstract

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A polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A, as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 9 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of said polypeptide, as well as separation matrices comprising the multimers or polypeptides.

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Patent Owner(s)

Patent OwnerAddress
CYTIVA BIOPROCESS R&D ABBJORKGATAN 30 UPPSALA 751 84

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ander, Mats Uppsala, SE 38 237
Bauren, Goran Uppsala, SE 7 150
Bjorkman, Tomas Uppsala, SE 41 362
Rodrigo, Gustav Uppsala, SE 43 350

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