Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof
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United States of America Patent
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Feb 20, 2018
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Aug 22, 2016
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Aug 27, 2007
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Abstract
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.
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