Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders
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United States of America Patent
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Feb 13, 2018
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app pub date -
Apr 3, 2009
filing date -
Oct 3, 2006
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Abstract
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant viral vector containing the transgene to the spinal cord. The viral vector delivers the transgene which expresses the encoded recombinant viral gene product. The viral gene product comprises HIF1-alpha. Also provided are compositions for delivery of a transgene product to a subject's spinal cord.
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