Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
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United States of America Patent
Stats
-
Feb 13, 2018
Grant Date -
Dec 19, 2013
app pub date -
May 8, 2013
filing date -
Apr 11, 2008
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
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Cited Art Landscape
Patent Citation Ranking
- 24 Citation Count
- A61K Class
- 98.50 % this patent is cited more than
- 7 Age
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