Antibodies with engineered IgG Fc domains
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United States of America Patent
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Feb 13, 2018
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app pub date -
Aug 30, 2013
filing date -
Oct 23, 2012
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Abstract
Antibody Fc polypeptides are provided that efficiently bind to both Fcγ and Fcα receptors. In certain aspects, a Fc polypeptide comprises a chimeric IgG CH2 domain having a α1 loop from IgA and an IgA CH3 domain. Recombinant antibodies comprising Fc polypeptides of the embodiments and methods for making and using such antibodies are likewise provided.
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