Process for making duocarmycin prodrugs

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United States of America Patent

PATENT NO 9890159
SERIAL NO

15316444

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Abstract

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The present invention relates to a process comprising converting a compound of formula (I) into a compound of formula (II) by reaction with an organolithium reagent, which compound can be further converted into duocarmycin analogs consisting of a DNA-alkylating and a DNA-binding part, and still further into corresponding antibody-drug conjugates.

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Patent Owner(s)

Patent OwnerAddress
BYONDIS B VMICROWEG 22 NIJMEGEN 6545 CM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beusker, Patrick Henry Nijmegen, NL 17 525
Coumans, Rudy Gerardus Elisabeth Nijmegen, NL 18 108
De, Groot Franciscus Marinus Hendrikus Nijmegen, NL 12 493
Elgersma, Ronald Christiaan Nijmegen, NL 11 58
Huijbregts, Tijl Nijmegen, NL 7 46
Joosten, Johannes Albertus Frederikus Nijmegen, NL 12 133
Menge, Wiro Nijmegen, NL 1 6
Spijker, Henri Johannes Nijmegen, NL 10 135

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