Evaluation method and screening method for sphingosine-1-phosphate 1 (S1P1) receptor agonists

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United States of America Patent

PATENT NO 9885703
SERIAL NO

14912827

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Abstract

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It has been found that a main effect (immunosuppressive activity) of an S1P1 receptor agonist correlates with the selectivity for cells expressing a combination of an S1P1 receptor with Gαi2 or Gαi3, and that an adverse effect (cardiotoxicity) of an S1P1 receptor agonist correlates with the selectivity for cells expressing a combination of an S1P1 receptor with Gαi1.

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Patent Owner(s)

Patent OwnerAddress
MEIJI SEIKA PHARMA CO LTDCHUO-KU TOKYO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ninomiya, Tomohisa Yokohama, JP 7 7
Yoshida, Satoshi Yokohama, JP 330 2967

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