Ultrahigh throughput microinjection device
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United States of America Patent
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Feb 6, 2018
Grant Date -
Oct 22, 2015
app pub date -
Feb 21, 2013
filing date -
Feb 21, 2012
priority date (Note) -
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status (Latency Note)
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Abstract
Many applications in cell biology, genetic engineering, cell-based therapeutics, and drug discovery require precise and safe methods for introducing membrane-impermeable molecules into cells. This can be implemented satisfactorily by microinjection. However, disadvantages of traditional manual microinjection include high degree of operator skill, low throughput and labor-intensiveness. Many studies have focused on developing automated and high-throughput systems for microinjection to address these limitations. However, none have provided sufficient throughput for applications such as ex vivo cell therapy, where manipulation of many cells is helpful.
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