PEG-urate oxidase conjugates and use thereof
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United States of America Patent
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Feb 6, 2018
Grant Date -
Jun 9, 2016
app pub date -
Jul 22, 2015
filing date -
Aug 6, 1998
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Abstract
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
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