High affinity antibodies to human IL-6 receptor
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United States of America Patent
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Feb 6, 2018
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Apr 22, 2016
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Jun 2, 2006
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Abstract
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
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