Disulfide masked prodrug compositions and methods

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United States of America Patent

PATENT NO 9884886
SERIAL NO

14648716

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Abstract

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The present invention relates to disulfide masked prodrug compounds of formula I, compositions and methods that are amenable to bioactivation by a reducing agent such as glutathione:

description='In-line Formulae' end='lead'W—P(V)LG  (Formula I),description='In-line Formulae' end='tail'

wherein P(V)LG is a pentavalent phosphorus leaving group; and W is:

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Butora, Gabor Martinsville, US 41 552

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