Compounds and methods to treat organophosphorus poisoning

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United States of America Patent

PATENT NO 9884052
SERIAL NO

14951106

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF IOWA RESEARCH FOUNDATION200 S CAPITOL STREET 2660 UNIVERSITY CAPITOL CENTRE IOWA CITY IA 52242

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Quinn, Daniel M Iowa City, US 5 14
Topczewski, Joseph John Iowa City, US 3 5

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