Cerebrospinal diffusion phantom
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United States of America Patent
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Jan 30, 2018
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app pub date -
Sep 4, 2015
filing date -
Sep 4, 2015
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Abstract
Disclosed herein are cerebrospinal diffusion phantoms which include a housing having a shape and size configured for insertion into a magnetic resonance coil in one or more preselected poses. A scaffold support structure is mounted on an interior of said housing and a plurality of elongated diffusion mimicking members supported on the support array. The elongated diffusion mimicking members are affixed to the scaffold support structure such that elongated diffusion mimicking members extend in directions needed to substantially emulate a 3 dimensional arrangement of cerebrospinal diffusion fiber tracts in a living organism; as well as modules for elimination of resolution based-bias, angular accuracy evaluation, diffusion rate calibration, and quality assurance image referencing. Each elongated diffusion mimicking member includes an aqueous component which can undergo diffusion along the elongated diffusion mimicking member. The phantom includes a cerebrospinal tissue mimic matrix material contained in the housing enveloping the array of elongated diffusion mimicking members. The housing is made of a material whose magnetic susceptibility substantially matches that of the cerebrospinal mimic matrix material.
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