MEK1 mutation conferring resistance to RAF and MEK inhibitors

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United States of America Patent

PATENT NO 9880169
SERIAL NO

15011003

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Abstract

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Nucleic acids and proteins having a mutant MEK sequence, and methods concerning identification of patients having resistance to treatment with anti-cancer agents, specifically inhibitors of RAF or MEK are provided. Methods of treatment and for optimizing treatment for patients having a mutation in a MEK1 sequence are also provided.

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Patent Owner(s)

Patent OwnerAddress
DANA-FARBER CANCER INSTITUTE INC450 BROOKLINE AVENUE BOSTON MA 02215

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Emery, Caroline Cambridge, US 19 8
Garraway, Levi A Newton, US 24 152
Wagle, Nikhil Brookline, US 6 0

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