Modulators of alpha-synuclein toxicity

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United States of America Patent

PATENT NO 9879257
SERIAL NO

14666517

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Abstract

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Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.

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Patent Owner(s)

Patent OwnerAddress
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH455 MAIN STREET CAMBRIDGE MA 02142-1479

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cashikar, Anil Martinez, US 4 33
Gitler, Aaron D Foster City, US 15 69
Lindquist, Susan L Cambridge, US 34 256

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