Restoring phosphorylation of a novel PINK1 substrate to treat parkinson's disease
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United States of America Patent
Stats
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Jan 30, 2018
Grant Date -
Oct 22, 2015
app pub date -
Nov 7, 2013
filing date -
Nov 7, 2012
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm.
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International Classification(s)
- 2013 Application Filing Year
- A61K Class
- 12711 Applications Filed
- 11051 Patents Issued To-Date
- 86.95 % Issued To-Date
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- 0 Citation Count
- A61K Class
- 0 % this patent is cited more than
- 7 Age
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