Method for screening substance capable of inhibiting abnormal splicing causative of onset or progress of disease

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United States of America Patent

PATENT NO 9879014
SERIAL NO

14904609

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Abstract

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A compound and a pharmaceutical composition for disease associated with an abnormal splice variant, use of the compound and the pharmaceutical composition, or a screening method of the compound and the pharmaceutical composition are provided. One or more embodiments disclose a compound expressed by the following formula (I) or (I′) or prodrugs or pharmaceutically acceptable salts thereof. Another one or more embodiments disclose a screening method using a DNA construct that is fused, arranged, or constructed so as to express different reporter genes for a wild-type splice variant and an abnormal splice variant that contributes to the development or progression of disease;

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Patent Owner(s)

Patent OwnerAddress
KYOTO UNIVERSITY36-1 YOSHIDA-HONMACHI SAKYO-KU KYOTO-SHI KYOTO 6068501 JAPAN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hagiwara, Masatoshi Kyoto, JP 36 151
Hosoya, Takamitsu Tokyo, JP 32 159
Yoshida, Suguru Tokyo, JP 71 484

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