Delivery of agents using interfering nanoparticles
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United States of America Patent
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Jan 30, 2018
Issued Date -
N/A
app pub date -
Dec 9, 2016
filing date -
Mar 16, 2010
priority date (Note) -
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Abstract
Provided are compositions and methods for delivery of therapeutic agents, such as chemically stabilized antisense oligonucleotides useful in RNA silencing. The compositions include interfering nanoparticles (iNOPs) associated with one or more agents. Several functional iNOP derivatives are provided which allow for targeted delivery of agents to specific cell types as well as exhibiting reduced cellular toxicity.
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