Syndecan peptides and polypeptides as inhibitors of vascular endothelial growth factor receptor-2 (VEGFR2) and very late antigen-4 (VLA-4)

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United States of America Patent

PATENT NO 9878007
SERIAL NO

15043951

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Abstract

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Peptides derived from amino acid residues 210 to 240 of human syndecan 1 and methods of use of such peptides are described. These peptides can inhibit activation of α4β1 integrin (also known as very late antigen-4, VLA-4), and can inhibit engagement of VLA-4 with vascular endothelial growth factor receptor-2 (VEGFR2), thereby preventing tumor cell growth and tissue invasion.

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Patent Owner(s)

Patent OwnerAddress
WISCONSIN ALUMNI RESEARCH FOUNDATION614 WALNUT STREET 13TH FLOOR MADISON WI 53726

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jung, Oisun Madison, US 3 2
Rapraeger, Alan Stoughton, US 9 19

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