Methods and compositions for regulating SRCA2A expression levels in myocardial infarction
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United States of America Patent
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Jan 30, 2018
Grant Date -
May 5, 2016
app pub date -
Jun 24, 2014
filing date -
Jun 26, 2013
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Abstract
The disclosure provides methods and compositions for increasing SERCA2a expression levels in a mammalian subject in need thereof. The methods comprise administering to the subject a therapeutic amount of an aromatic-cationic peptide to subjects in need thereof. In some embodiments, the aromatic-cationic peptide is D-Arg-2′6′-Dmt-Lys-Phe-NH2, or a pharmaceutically acceptable salt thereof such as acetate or trifluoroacetate salt. In some embodiments, the subject has suffered a myocardial infarction.
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