Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
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United States of America Patent
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Jan 30, 2018
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Aug 31, 2015
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Sep 5, 2014
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Abstract
The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardio renal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
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