Rotigotine-containing transdermal absorption preparation with improved stability
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United States of America Patent
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Jan 30, 2018
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app pub date -
Nov 17, 2016
filing date -
May 21, 2014
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Abstract
A method for preparing a transdermal absorption composition includes mixing rotigotine and an antioxidant at a weight ratio of 1:0.0001 to 0.1. A transdermal therapeutic system includes a substrate and a drug-containing adhesive layer disposed on the substrate and including an antioxidant at a weight ratio of 1:0.0001 to 0.1. The method and system of the present invention suppress the crystallization of rotigotine as well as the generation of related substances, thereby increasing the long-term storage stability of a therapeutic product containing rotigotine or related substances.
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