Method for predicting response to trastuzumab therapy in breast cancer patients

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United States of America Patent

PATENT NO 9873916
SERIAL NO

14113776

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Abstract

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This invention relates to a composition and a method for prediction of a response to Trastuzumab therapy in a breast cancer patient, and more specifically, a composition, a kit, a DNA chip, and a method for predicting a response to Trastuzumab therapy by using polynucleotides each comprising a nucleotide sequence represented by any of SEQ ID NOs: 1 to 9, 11 to 19, and 21 to 23 in the Sequence Listing or a nucleotide sequence derived therefrom by substitution of u with t, mutants thereof, derivatives thereof, or fragments thereof comprising at least 16 continuous nucleotides, or a polynucleotide comprising a complementary sequence thereof, and using an increase or decrease in Her2 protein expression level as an indicator.

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Patent Owner(s)

Patent OwnerAddress
TORAY INDUSTRIES INC1-1 NIHONBASHI-MUROMACHI 2-CHOME CHUO-KU TOKYO 1038666 JAPAN
KYOTO UNIVERSITY36-1 YOSHIDA-HONMACHI SAKYO-KU KYOTO-SHI KYOTO 6068501 JAPAN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kozono, Satoko Kamakura, JP 63 125
Myomoto, Akira Kamakura, JP 5 25
Sato, Fumiaki Kyoto, JP 179 2039
Shimizu, Kazuharu Kyoto, JP 12 151
Toi, Masakazu Kyoto, JP 12 25
Tsujimoto, Gozoh Kyoto, JP 15 43
Ueno, Takayuki Kyoto, JP 34 110
Wang, Zhipeng Kyoto, JP 57 76

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