High-yield method for rapidly conjugating ribonucleic acid (RNA) to diethylenetriamine pentaacetic acid (DTPA)

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United States of America Patent

PATENT NO 9873874
SERIAL NO

15212697

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Abstract

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The invention discloses a high-yield method for preparing a ribonucleic acid (RNA)-diethyltriamine pentaacetic acid (DTPA) conjugate. The conjugate is prepared by conjugating a RNA or locked nucleic acid (LNA) having an amino group to p-isothiocyanate benzyl-DTPA (SCN-Bn-DTPA) or DTPA anhydride with heating under microwave.

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Patent OwnerAddress
INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL EXECUTIVE YUAN R O CNO 1000 WENHUA RD JIAAN VILLAGE LONGTAN DISTRICT TAOYUAN CITY 32546

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hu, Chia-Yu Taoyuan, TW 10 16
Wang, Mei-Hui Taoyuan, TW 45 398
Yang, Chun-Hung Taoyuan, TW 4 5

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