Methods of making implantable collagen fiber
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United States of America Patent
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Jan 23, 2018
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app pub date -
Feb 10, 2015
filing date -
Nov 2, 2011
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Abstract
The invention relates to implantable collagen devices made by seeding at least one elongate collagen construct, e.g., comprising at least one elongate synthetic collagen fiber with a plurality of cells and applying a strain and/or stress to the at least one elongate collagen fiber to induce the cells to differentiate into target phenotypes, e.g., tendon or ligament phenotype cells (and/or fibroblasts), typically with an extracellular matrix of collagen to organize into a tissue on the at least one collagen fiber.
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