Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
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United States of America Patent
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Jan 23, 2018
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Nov 5, 2012
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Dec 18, 2006
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Abstract
The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
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