TFPI inhibitors and methods of use

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United States of America Patent

PATENT NO 9873720
SERIAL NO

14584393

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Abstract

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The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. Peptide complexes also are provided. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.

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Patent Owner(s)

Patent OwnerAddress
TAKEDA PHARMACEUTICAL COMPANY LIMITED1-1 DOSHOMACHI 4-CHOME CHUO-KU OSAKA-SHI OSAKA 541-8645

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dockal, Michael Vienna, AT 47 164
Hartmann, Rudolf Bisamberg, AT 31 298
Osterkamp, Frank Berlin, DE 31 175
Polakowski, Thomas Berlin, DE 19 110
Reineke, Ulrich Berlin, DE 34 219
Scheiflinger, Friedrich Vienna, AT 107 597

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