Structure-based peptide inhibitors of P53 aggregation as a new approach to cancer therapeutics

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United States of America Patent

PATENT NO 9873718
SERIAL NO

14889604

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Abstract

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This invention relates, e.g., to an inhibitory peptide or CPP inhibitor which specifically binds to p53 having an aberrant conformation (e.g., is aggregated or misfolded) and inhibits p53 amyloidogenic aggregation or restores proper folding of the misfolded protein. Methods of using the inhibitory peptide or CPP inhibitor (e.g. to treat subjects having tumors that comprise aggregated p53) are described.

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Patent Owner(s)

Patent OwnerAddress
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA1111 FRANKLIN STREET TWELFTH FLOOR OAKLAND CA 94607-5200

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Eisenberg, David S Los Angeles, US 13 21
Jiang, Lin Los Angeles, US 66 196
Soragni, Alice Los Angeles, US 4 1

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