TRH binding site in human CNS
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United States of America Patent
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Jan 23, 2018
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Dec 17, 2015
app pub date -
Dec 18, 2013
filing date -
Dec 19, 2012
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Abstract
The invention relates to a novel thyrotropin releasing hormone (TRH) receptor subtype in human central nervous system (CNS) that is pharmacologically distinct from the TRH receptor subtype in human pituitary. The invention provides a means to understand how the central actions of TRH are mediated and to isolate and characterize the novel receptor, as well as methods applicable to research and development of diagnostic and therapeutic applications in human CNS disorders.
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