Vitamin D receptor/SMAD genomic circuit gates fibrotic response
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United States of America Patent
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Jan 23, 2018
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Oct 23, 2015
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Apr 24, 2013
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Abstract
The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.
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