Multiparticles safeguarded against ethanolic dose-dumping
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United States of America Patent
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Jan 23, 2018
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app pub date -
May 22, 2015
filing date -
May 26, 2014
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Abstract
The invention relates to an oral pharmaceutical dosage form providing resistance against dose dumping in aqueous ethanol and comprising a pharmacologically active ingredient embedded in a matrix material,
- wherein the matrix material comprises an alkyl cellulose and a heteropolysaccharide; andwherein the relative weight ratio of heteropolysaccharide to alkyl cellulose is within the range of from 1:20 to 20:1; andwherein the total content of alkyl cellulose and heteropolysaccharide is at least 35 wt.-%, relative to the total weight of the dosage form. A process of producing the dosage form and methods of using the dosage form, for example to treat pain, are also disclosed.
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