Transgenic non-human mammal for producing chimeric human immunoglobulin E antibodies

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United States of America Patent

PATENT NO 9872483
SERIAL NO

14900586

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Abstract

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The invention relates to a transgenic non-human mammal comprising human immunoglobulin mu and epsilon heavy-chain constant transgenes Cμ and Cε inserted in place of endogenous mu heavy-chain switch sequence Sμ, and its use for producing chimeric human immunoglobulin E antibodies specific for an antigen of interest.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITE DE LIMOGES33 RUE FRANCOIS MITTERAND LIMOGES 87000
B CELL DESIGN87069 LIMOGES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bosselut, Marie Condar-sur-Vienne, FR 1 5
Cogne, Michel Isles, FR 3 37
Cuvillier, Armelle Saint-Jouvent, FR 3 5
Laffleur, Brice Limoges, FR 2 5

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