Biomarker sensing based on nanofluidic amplification and resonant optical detection
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United States of America Patent
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Jan 16, 2018
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Mar 15, 2013
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May 7, 2012
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Abstract
Provided is a sensor platform that includes a substrate, a plurality of nanochannels disposed on the substrate, and a plurality of electrodes, a waveguide disposed on the substrate and an analysis chamber and a reference chamber disposed on the substrate. Each electrode extends substantially across a width of the plurality of nanochannels. At least one analysis optical resonator is disposed in the analysis chamber and is optically coupled to at least a portion of the waveguide. The at least one analysis optical resonator is in fluid communication with at least one of the plurality of nanochannels. At least one reference optical resonator is disposed in the reference chamber and is optically coupled to at least a portion of the waveguide. The at least one reference optical resonator is in fluid communication with at least one other of the plurality of nanochannels.
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