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United States of America Patent

PATENT NO 9868956
SERIAL NO

13376068

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to a method of making a polypeptide comprising an orthogonal functional group, said orthogonal functional group being comprised by an aliphatic amino acid or amino acid derivative, said method comprising providing a host cell; providing a nucleic acid encoding the polypeptide of interest; providing a tRNA-tRNA synthetase pair orthogonal to said host cell; adding an amino acid or amino acid derivative comprising the orthogonal functional group of interest, wherein said amino acid or amino acid derivative is a substrate for said orthogonal tRNA synthetase, wherein said amino acid or amino acid derivative has an aliphatic carbon backbone; and incubating to allow incorporation of said amino acid or amino acid derivative into the polypeptide of interest via the orthogonal tRNA-tRNA synthetase pair. The invention also relates to certain amino acids, and to polypeptides comprising same.

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Patent Owner(s)

Patent OwnerAddress
UNITED KINGDOM RESEARCH AND INNOVATIONNORTH STAR AVENUE 2ND FLOOR DAVID PHILIPS BUILDING POLARIS HOUSE SWINDON SN2 1FL

International Classification(s)

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  • 2010 Application Filing Year
  • C12P Class
  • 1859 Applications Filed
  • 1029 Patents Issued To-Date
  • 55.36 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201020112012201320142015201620172018201920202021202220230255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chin, Jason Cambridge, GB 30 410
Deiters, Alexander Raleigh, US 29 423
Lusic, Hrvoje Raleigh, US 4 22
Neumann, Heinz Gottingen, DE 11 56
Nguyen, Duy P Cambridge, GB 6 21

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Patent Citation Ranking

  • 2 Citation Count
  • C12P Class
  • 56.21 % this patent is cited more than
  • 7 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges1277890732173101 - 1011 - 2021 - 3031 - 4051 - 6071 - 80010020030040050060070080090010001100120013001400

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