Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly

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United States of America Patent

PATENT NO 9868948
APP PUB NO 20130303396A1
SERIAL NO

13889484

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Abstract

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The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

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Patent Owner(s)

Patent OwnerAddress
CHUGAI SEIYAKU KABUSHIKI KAISHA5-1 UKIMA 5-CHOME KITA-KU TOKYO 1158543 ?1158543

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Igawa, Tomoyuki Shizuoka, JP 244 5997
Ishii, Shinya Shizuoka, JP 71 1328
Maeda, Atsuhiko Shizuoka, JP 91 2389
Nakai, Takashi Shizuoka, JP 125 1382

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