Hydrophobic modified pres-derived peptides of hepatitis B virus (HBV) and their use as vehicles for the specific delivery of compounds to the liver

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United States of America Patent

PATENT NO 9868768
SERIAL NO

12864197

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Abstract

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The present invention relates to hydrophobic modified preS-derived peptides of hepatitis B virus (HBV) which are versatile vehicles for the specific delivery of compounds to the liver, preferably to hepatocytes, in vitro as well as in vivo. Any kind of compound, but in particular drugs, such as interferons, viral reverse transcriptase inhibitors or core assembly inhibitors, and/or labels can be specifically targeted to the liver and so be enriched in the liver. This liver targeting can further be used for the targeted diagnosis, prevention and/or treatment of liver diseases or disorders, such as hepatitis, malaria, hepatocellular carcinoma (HCC), as well as for the prevention of HAV, HBV, HCV and/or HDV infection. The present invention relates to pharmaceutical compositions comprising said hydrophobic modified preS-derived peptide(s) and the compound(s) to be specifically delivered to the liver. The present invention furthermore relates to a method for the combined treatment of a liver disease and the prevention of HAV, HBV, HCV and/or HDV infection. The present invention relates also to the use of the preS-derived peptides in gene therapy and the delivery of immunogenic epitopes for hepatocyte-mediated antigen presentation to activate liver-directed immunological responses.

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Patent Owner(s)

Patent OwnerAddress
RUPRECHT-KARLS-UNIVERSITAT HEIDELBERGGRABENGASSE 1 HEIDELBERG 69117

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Haberkorn, Uwe Schwetzingen, DE 36 216
Mier, Walter Bensheim, DE 39 178
Urban, Stephan Neustadt, DE 20 36

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