Optical system and assay chip for probing, detecting and analyzing molecules

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United States of America Patent

PATENT NO 9863880
SERIAL NO

14543867

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Abstract

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Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

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Patent Owner(s)

Patent OwnerAddress
QUANTUM-SI INCORPORATED530 OLD WHITFIELD STREET GUILFORD MA 06437

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bellofiore, Anthony Glastonbury, US 8 191
Cipriany, Benjamin Branford, US 44 889
Cohen, Adam E Cambridge, US 18 358
Ferrigno, Michael Farmington, US 11 208
Glenn, Paul E Wellesley, US 53 843
Gyarfas, Brett J Guilford, US 30 753
Jewell, Jack Boulder, US 29 505
Kabiri, Ali Madison, US 59 845
Lackey, Jeremy Guilford, US 76 1160
Rothberg, Jonathan M Guilford, US 567 39206
Schmid, Gerard Guilford, US 99 1172
Sickler, Jason W Madison, US 47 1084
West, Lawrence San Jose, US 4 187

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