Marker for prenatal diagnosis and monitoring
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United States of America Patent
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Jan 9, 2018
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Feb 1, 2016
filing date -
Jun 4, 2004
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Abstract
The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
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