Conformational probes and methods for sequencing nucleic acids
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United States of America Patent
Stats
-
Jan 9, 2018
Issued Date -
N/A
app pub date -
Apr 19, 2016
filing date -
Jun 18, 2010
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
This disclosure provides a method of determining a sequence of nucleotides for a nucleic acid template. The method can include the steps of contacting the nucleic acid template with a conformationally labeled polymerase and at least four different nucleotide species under conditions wherein the conformationally labeled polymerase catalyzes sequential addition of the nucleotide species to form a nucleic acid complement of the nucleic acid template, wherein the sequential addition of each different nucleotide species produces a conformational signal change from the conformationally labeled polymerase and wherein the rate or time duration for the conformational signal change is distinguishable for each different nucleotide species; detecting a series of changes in the signal from the conformationally labeled polymerase under the conditions; and determining the rates or time durations for the changes in the signal, thereby determining the sequence of nucleotides for the nucleic acid template.
First Claim
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Family
International Classification(s)
- 2016 Application Filing Year
- C12Q Class
- 3975 Applications Filed
- 2340 Patents Issued To-Date
- 58.87 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 1 Citation Count
- C12Q Class
- 57.71 % this patent is cited more than
- 7 Age
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| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Jul 9, 2025 |
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