Assembly of bispecific antibodies
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United States of America Patent
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Jan 9, 2018
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app pub date -
Apr 11, 2014
filing date -
Oct 11, 2011
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Abstract
Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
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