Compositions and methods relating to hindering DOT1L recruitment by MLL-fusion proteins

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United States of America Patent

PATENT NO 9862746
SERIAL NO

14763596

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Abstract

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The present invention relates to MLL fusion proteins (e.g., AF9 and ENL), which activate target genes in part via recruitment of histone methyltransferase DOT1L. In particular, the present invention provides the AF9/ENL binding site in DOT1L and agents that block the protein-protein interactions between AF9/ENL and DOT1L, therefore inhibiting the activity of DOT1L, and inhibiting MLL-fusion protein associated leukemia.

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Patent OwnerAddress
THE REGENTS OF THE UNIVERSITY OF MICHIGAN1600 HURON PARKWAY 2ND FLOOR OFFICE OF TECHNOLOGY TRANSFER ANN ARBOR MI 48109-2590

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hess, Jay Ann Arbor, US 4 84
Nikolovska-Coleska, Zaneta Ann Arbor, US 23 355
Shen, Chenxi Beijing, CN 2 1

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