Inhibitors of the renal outer medullary potassium channel

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United States of America Patent

PATENT NO 9862720
SERIAL NO

15505620

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Abstract

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The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ding, Fa-Xiang Staten Island, US 43 119
Dong, Shuzhi Plainsboro, US 27 92
Jiang, Jinlong Scotch Plains, US 49 459
Suzuki, Takao Shanghai, CN 269 3417
Vacca, Joseph P Telford, US 111 1099
Xu, Shouning Shanghai, CN 5 11

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