Processes for making compounds useful as inhibitors of ATR kinase

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United States of America Patent

PATENT NO 9862709
APP PUB NO 20150274710A1
SERIAL NO

14678489

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Abstract

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The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.

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Patent Owner(s)

Patent OwnerAddress
VERTEX PHARMACEUTICALS INCORPORATED50 NORTHERN AVENUE BOSTON MA 02210

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Angell, Paul Carlsbad, US 13 216
Charrier, Jean-Damien Abingdon, GB 174 6159
Durrant, Steven John Abingdon, GB 37 1623
Hughes, Robert Michael San Diego, US 20 403
Littler, Benjamin Joseph Carlsbad, US 17 661
Pierard, Francoise Yvonne Theodora Marie Abingdon, GB 8 295
Shi, Yi Natick, US 143 760
Siesel, David Andrew San Diego, US 19 623
Studley, John Abingdon, GB 53 1154
Urbina, Armando San Diego, US 7 186

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