Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer
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United States of America Patent
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Jan 9, 2018
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app pub date -
Jan 21, 2014
filing date -
Jan 23, 2013
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Abstract
Described herein are analogs of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogs having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed.
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