Potent and selective inhibitors of monoamine transporters; method of making; and use thereof

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United States of America Patent

PATENT NO 9862679
SERIAL NO

14772486

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Abstract

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Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephrine (NE) reuptake via their respective transporters, DAT, SERT and NET. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (hyperactivity) disorder, depressive disorders, bipolar disorder or other neuropsychiatric disorders sleep disorders or cognitive impairment using the compounds.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESOFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTES OF HEALTH 6011 EXECUTIVE BOULEVARD SUITE 325 MSC 7660 BETHESDA MD 20892-7660

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cao, Jianjing Ellicott City, US 6 25
Newman, Amy Hauck Phoenix, US 17 32
Okunola-Bakare, Oluyomi M Beltsville, US 4 17

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