Polymeric prodrug of disulfiram and application thereof
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United States of America Patent
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Jan 9, 2018
Issued Date -
N/A
app pub date -
Dec 8, 2015
filing date -
Dec 11, 2014
priority date (Note) -
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Abstract
Polymer/drug conjugates that can selectively target and kill cancer cells are described. Conjugates can include a copolymer formed by the reaction of a biocompatible hydrophilic component and a disulfiram derivative. The copolymer reaction product can include additional functional groups pendant to the backbone via a disulfide linkage, for instance copper chelators. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.
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