Processable single chain molecules and polypeptides made using same
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United States of America Patent
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Jan 2, 2018
Grant Date -
Aug 8, 2013
app pub date -
Jul 11, 2011
filing date -
Jul 9, 2010
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Abstract
The present invention features inter alia nucleic acid molecules which encode polypeptides comprising a single chain Fc region and the polypeptides they encode. The Fc moieties of these constructs are linked by a cleavable scFc linker which is adjacent to at least one enzymatic cleavage site, e.g., an intracellular processing site. The resulting processed molecules comprise two polypeptide chains and substantially lack the extraneous amino acid sequence found in single chain Fc linker molecule. Methods of making and using these dimeric molecules are also described.
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