Refolding proteins using a chemically controlled redox state

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United States of America Patent

PATENT NO 9856287
SERIAL NO

15422327

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Abstract

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A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.

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Patent Owner(s)

  • AMGEN INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hart, Roger Needham, US 23 161
Keener,, III Ronald Nixon Newbury Park, US 5 16
Shultz, Joseph Edward Binningen, CH 14 46

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