Reagents for universal site-specific labeling and modifications of nucleic acids
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United States of America Patent
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Jan 2, 2018
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Mar 17, 2015
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Mar 17, 2015
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Abstract
The present invention discloses a method of harnessing versatile phosphoramidation reactions to regioselectively link a group of alkynyl-/azido-containing compounds to post-synthetic nucleic acids primed with phosphate at the 5′ termini. The method includes steps of: (a) monophosphoramidating H2N(CH2)nNH2 to the 5′ end of the nucleic acid to form an intermediate 1 where n is an integer from 2 to 6, and the intermediate 1 has a formula of:
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